Digitalization, aka Industry 4.0, is changing the future of the petrochemical, energy, and related industries, with respect to long-term sustainability (e.g., environmental responsibility, cost efficiencies). Moreover, digitalization is expected to change the way these industries construct and operate assets, that is, to produce at a higher quality products and services with less human and natural resources, environmental impacts, and in a safe manner. First movers are implementing digital technology across operational areas with the use of cloud and cognitive computing and automation—all involving the integration of business processes and digitalization technology. However, this speed of adoption for a company is complex; governed by the speed of its change management within a transforming enterprise. What is the status of adoption? What types of barriers to implementation do the refining and petrochemical industries encounter? What successes have they achieved thus far?