The IEA estimates that about half of the technologies needed to deliver net zero emissions by 2050 are not currently commercially competitive. Innovation is fundamental to achieving national pledges for net zero, accounting for 90% of global GDP. What is needed to accelerate the chain from laboratories to commercial application to financing to deployment? Should multiple tracks—such as hydrogen, carbon capture, utilization, and storage (CCUS), and fusion—move forward in parallel to mitigate risk? Where should efforts be focused to achieve success?